Optimization of the Statin Therapy Algorithm in Outpatient Practice: Adherence and Economic Benefits

Aim . To study adherence to recommended treatment, additional clinical and economic benefits of a titration-free statin therapy regimen. Material methods Ambulatory patients (n=300) with high or very risk hypercholesterolemia who have indications for treatment primary secondary prevention cardiovascular diseases is included in non-randomized trial. Patients are divided into 2 groups. Group 1 had titration regimen statins accordance current recommendations (group 1A [n=50] – prevention; group 1B [n=100] prevention). received fixed doses 2A 2B were prescribed atorvastatin (10-80 mg/day) rosuvastatin (10- 40 mg/day). visits the doctor after 1, 3, 6 12 months from start use, 3 months. Treatment adherence, effects on surrogate hard endpoints, cost-effectiveness two regimens evaluated. Results The target level low-density lipoprotein cholesterol (LDL-C) was achieved 56.4% versus 53.4% 1. average LDL-C decreased by 1.84±0.44 mmol / l decrease 1.61±0.47 L costeffectiveness ratio 9658.72 rubles 8341.73 patient within year. An increase annual costs per compared 75.76 reduced relative developing combined endpoint 1% Conclusion use allowed us not only more effectively control LDL-c levels traditional regimen, but also obtain advantages risk.